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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HGS All Species: 22.42
Human Site: Y567 Identified Species: 44.85
UniProt: O14964 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14964 NP_004703.1 777 86192 Y567 M P A F P L P Y A Q L Q A M P
Chimpanzee Pan troglodytes XP_511742 777 85768 Y567 M P A F P L P Y A Q L Q A M P
Rhesus Macaque Macaca mulatta XP_001111673 777 86015 Y567 M P A F P L P Y A Q L Q A M P
Dog Lupus familis XP_540486 782 86005 A571 P A F S L P Y A Q L Q A M P P
Cat Felis silvestris
Mouse Mus musculus Q99LI8 775 85996 Y565 M P A F P L P Y A Q L Q A M P
Rat Rattus norvegicus Q9JJ50 776 86228 Y566 M P A F P L P Y A Q L Q A M P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001083588 751 84100 Y544 M P A F S L P Y A Q L Q S L P
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q960X8 760 85396 P538 P P F P Y M P P S A V P Q H G
Honey Bee Apis mellifera XP_393989 830 92147 P542 A V S G F I G P S Q G S P V R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783582 784 87687 P564 H A P Y G M A P P Q G S Y P S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40343 622 70927 N422 G K I S E I M N I Y D R L L E
Red Bread Mold Neurospora crassa Q7RZJ2 724 79729 R524 Q Y M P Y D R R S S M V G P P
Conservation
Percent
Protein Identity: 100 95.5 98.8 92.3 N.A. 93.3 93.4 N.A. N.A. N.A. 80 N.A. N.A. 41.7 47.7 N.A. 49.4
Protein Similarity: 100 96.6 98.9 94.2 N.A. 95.6 95.6 N.A. N.A. N.A. 87.5 N.A. N.A. 55.7 60.9 N.A. 61.3
P-Site Identity: 100 100 100 6.6 N.A. 100 100 N.A. N.A. N.A. 80 N.A. N.A. 13.3 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 6.6 N.A. 100 100 N.A. N.A. N.A. 93.3 N.A. N.A. 33.3 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.2 24.9
Protein Similarity: N.A. N.A. N.A. N.A. 40.6 41
P-Site Identity: N.A. N.A. N.A. N.A. 0 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 17 50 0 0 0 9 9 50 9 0 9 42 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 0 0 0 0 9 0 0 0 0 % D
% Glu: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 9 % E
% Phe: 0 0 17 50 9 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 0 0 9 9 0 9 0 0 0 17 0 9 0 9 % G
% His: 9 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 0 9 0 0 17 0 0 9 0 0 0 0 0 0 % I
% Lys: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 9 50 0 0 0 9 50 0 9 17 0 % L
% Met: 50 0 9 0 0 17 9 0 0 0 9 0 9 42 0 % M
% Asn: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % N
% Pro: 17 59 9 17 42 9 59 25 9 0 0 9 9 25 67 % P
% Gln: 9 0 0 0 0 0 0 0 9 67 9 50 9 0 0 % Q
% Arg: 0 0 0 0 0 0 9 9 0 0 0 9 0 0 9 % R
% Ser: 0 0 9 17 9 0 0 0 25 9 0 17 9 0 9 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 9 0 0 0 0 0 0 0 0 9 9 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 9 17 0 9 50 0 9 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _